Dr. Eyad


Lippincott Illustrated Reviews-Pharmacology is a wide-spread book with simple language and figures, making it a useful book for the students of Medicine, Nursing, and Pharmacology. However, the book includes many scientific and graphical mistakes that should be made note of.

In this brief book I will be highlighting some mistakes in the current (sixth) edition of Lippincott Pharmacology. I will mention the page number, with a photo of the location of the mistake and why it is mistake, then the correction.

Some mistakes simply contradict a very well-known established scientific fact, in which case I may not mention references for the correction. For other mistakes, a reference or more for correction is mentioned. This book includes a total of 37 corrections, ten of which are considered relatively minor corrections, for which reason I put them at the end.

I hope both instructors and students will make use of this booklet for more authentic teaching and learning.

Eyad Qunaibi

PhD in Pharmacology from University of Houston, TX, USA

Associate Professor in Pharmacology at Jarash University, Jordan

February, 2017

Correction 1: Page 3:


Figure 1-01


In the comparison of IM vs. IV midazolam (Fig 1.3), there is a couple of issues:

  1. The IV curve should reach zero concentration (as in the dashed red line I added), intersecting with the IM curve. The way it is drawn originally in your figure shows as if IV injections give sustained levels as IM ones, which is not the case.
  2. The bioavailability after the IM injection (compared with the IV inj.) should be higher than shown in your fig. Bioavailability of 5 mg IM midazolam is somewhat between 87% and 100%. See:

with focus on the phrase (bioavailability was 1.0 for both drugs) meaning midazolam and diazepam.

with focus on the sentence (The absolute bioavailability of intramuscular midazolam was calculated in 11 patients as 87 +/- 18%).

Therefore, the alternative I suggest should look something like this figure:

Figure 2-02


Note a higher IM bioavailability than fig 1.3 and intersection of IV with IM curves.

Correction 2: Page 4:

Figure 3-05

Nasal inhalation is not a suitable title. It should be (Nasal preparations) or (Nasal spray and inhalation) for example. This is because the term ‘nasal inhalation’ means a preparation applied in the nose with the purpose of having it ‘inhaled’ to the respiratory system, which applies to inhaled anesthetics.

The very first example mentioned (oxymetazoline) is a nasal decongestant and its preparation is described as (nasal spray) and is never described as ‘inhalation’. Desmopressin preparation is usually described as spray rather than inhalation. Mometazone furoate preparation is described as either spray or inhalation.

However, I reemphasize that the preparation of oxymetazoline is never described as inhalation because it is not meant to be inhaled but to act locally as a decongestant.

Correction 3: Page 5:

Figure 7-07

Patients do not need to regulate dose with inhalation devices. They are in fact called
‘metered dose’ devices. This point can be omitted with the next disadvantage below it
(Some patients may have difficulty using inhalers, leading to variable dose).

Correction 4: Page 7:

Figure 8-08

It is confusing to include both weak acids and weak bases in the same figure. Notice that the figure included B and BH+, both of which were assigned for weak bases in Fig 1.7 in Lippincott. A pKa of 6.5 is for a weak acid, not a weak base.

Correction: the representation for a weak base should be separated from that of the weak acid, or it should be mentioned in the text that opposite predominance of protonated vs. deprotonated forms applies to weak base on the two sides of a pKa higher than 7 without including this in the figure.

Corrections 5: Page 7:

Fugure 9-09

At the arrow in the above text image, the phrase ‘per area’ should be added so that the sentence becomes: ‘The intestines receive much more blood flow than the stomach per area’…to make it clear that it is not the larger surface area of intestine we talk about here, because this last factor is already detailed in the next point (i.e. point 3. Total surface area available for absorption).

Correction 6: Page 9:

Under the title (E. Therapeutic equivalence) we read these sentences:


These sentences are contradictory with the sentence under the title (D. Bioequivalence). This is because: “two drugs that are bioequivalent” -as in the second sentence of the note above- necessarily achieve the two conditions for therapeutic equivalence that are mentioned in the first sentence of the note (i.e. similarity in “maximum serum drug concentration and the time required to reach peak concentration”), because these two bioequivalent drugs “show comparable bioavailability and similar times to achieve peak blood concentrations” as defined under (D. Bioequivalence). So, the conclusion “two drugs that are bioequivalent may not be therapeutically equivalent” is inconsistent with the sentences above.

In fact, therapeutic equivalence requires factors other than “max serum drug concentration and the time required to reach peak concentration”, which are the conditions of bioequivalence. Look at the FDA Orange Book: http://www.fda.gov/Drugs/DevelopmentApprovalProcess/ucm079068.htm#tecode, with focus on the title (Therapeutic equivalence).

Correction 7: Page 10:


First of all, extracellular fluid includes blood, and this is what Lippincott itself mentions in page 11 under the title (b. Extracellular fluid):


In addition, it is meant to say that many drugs accumulate inside cells, not in tissues, because tissues involve their interstitial fluid.

In the figure below, I show the concept of drug accumulation inside cells compared with interstitial fluid and plasma:


So, the sentence should be: Many drugs accumulate in cells, leading to higher concentrations in cells than in the interstitial fluid and blood.

Correction 8: Page 12:


Instead of “is lipophilic” it should be (has enough lipophilicity), because ethanol is mentioned at the end of the paragraph as an example, and ethanol is generally hydrophilic in deed, not lipophilic. So, (enough lipophilicity) is more accurate to describe ethanol.

Correction 9: Page 12:


This part of the sentence (and extend the duration of action) should be omitted because the relationship between half-life and duration of action is complex and not always proportional. For example, binding of a drug to the intracellular proteins or fats out of the site of action increases volume of distribution and t1/2 of that drug but decreases duration of its action because it decreases its concentration at the site of action below effective concentration (propofol as an example).

In addition, saying “any factor that increases Vd” may make the student think Vd can be manipulated, while in deed it is constant for a given drug.

If it was meant that the innate properties of a drug which increase its Vd also increase t1/2 then the sentence should read: (drugs with higher Vd have longer t1/2).

If, on the other hand, the disease states that can increase Vd of a drug are what the sentence is talking about, then the correlation is also complex. For example, being obese can increase the Vd of lipophilic drugs but is not known to increase its duration of action. Diseases that decrease plasma proteins not only increase distribution to extravascular compartments, but also increase delivery of the drug to the elimination organs.

In brief, the phrase (and extend the duration of action) should be omitted.

Correction 10: Page 13:


The underlined sentence is misleading because it makes the student think Clearance is equal to the amount of drug cleared, while it is the volume of blood from which the drug is cleared per unit time regardless of the amount of drug cleared.

One may argue that clearance is used to estimate the amount of drug cleared. However, clearance itself is not correctly defined anywhere in this chapter, making this sentence more problematic because a student would simply think it is “the amount of drug cleared”, which is in fact a common mistake among students!

CL is unique (constant) for a particular drug and a particular patient. Being constant means that it remains the same over a broad range of plasma concentrations (corresponding to a broad range of amounts of drug cleared).

Correction 11: Page 17:


Just the opposite is the case! Incompletely developed tubular secretory mechanism causes retention of certain drugs in the arterioles (vascular compartment) not the glomerular filtrate (tubular compartment). This is because secretory mechanisms cause secretion from blood into tubules, not reabsorption from tubules into blood. See the figure below for illustration:



Correction 12: Page 17:


It is confusing to use clearance interchangeably with excretion. Same is said about using eliminating interchangeably with excreting.

Clearance involves both processes of metabolism and excretion.

Also: Elimination involves both processes of metabolism and excretion.

Therefore, it is more accurate to say:

‘Excretion by other routes’….’Drug excretion may also occur’…..drug-metabolizing and drug-excreting organs’.

Correction 13: Page 20:


The highlighted sentence gives the wrong impression that changing the dosing frequency changes “the rate at which the steady state is approached’ without affecting Css value, especially that the sentence is mentioned under the title (Effect of dosing frequency). The sentence should be: Dosing frequency changes neither Css magnitude, nor the rate of achieving Css.

Correction 14: Page 21:

Steady-state concentration is almost achieved in 2 t1/2s in Fig. 1.25 in Lippincott, while it should be achieved in about 4-5 t1/2s (see correction 15).

The interval for t1/2 should be narrowed.


Correction 15: Page 22:


The t1/2 is disproportional with the time to achieve steady state concentration in Fig. 1.26 in Lippincott. In page 19 it is mentioned that “a drug reaches steady state in about four to five half-lives”.

In 2 t1/2s only 75% of the steady state concentration should be achieved, while a much higher concentration is achieved in this figure. The same mistake has occurred in the curves after increasing and decreasing the doses.

A correction can be made by halving the magnitude of elimination t1/2 indicated at the left extreme of the x-axis.

Correction 16: Page 23:


This wording makes the student think that the listed reactions are all truly phase II reactions and that the question is about which of them makes the metabolite readily excretable. While, in reality, all of them, except glucuronidation, are phase I reactions. The question needs to be as follows:

(While of the following is a phase II metabolic reaction that makes phase I metabolites readily excretable in urine?).

Correction 17: Page 29:


β-Receptors are not a good example for low spare receptor percentage because this is, at least, controversial. Other references mention just the opposite:

“Several studies have indicated that in humans and experimental animals, about 90% of β adrenoceptors in the heart are spare receptors.” (Katzung and Trevor’s Pharmacology Examination and Board Review, 11th edition p.22)

“Thus, adrenaline can elicit the maximum cardiac inotropic response even when 90% of the cardiac β1 adrenergic receptors are occupied by relatively irreversible antagonists. This indicates that the cardiac tissue possesses a large number of spare beta, receptors.” (Pharmacology and Pharmacotherapeutics, 24th Edition, 2015, p. 34)

Correction 18: Page 33:


In Fig 2.11 in Lippincott, the sentence in the rectangle is false and it should be:

In this example, approximately 12% of maximal receptor activity is shown basally (constitutively, without stimulation).

The two sentences are not the same although they may seem so at first glance.

The original sentence is false because it is based on the wrong assumption that an unoccupied basally-active receptor has the same activity as a full agonist-occupied receptor. This abolishes the whole concept of intrinsic activity and coupling efficiency!

In page 31 of the book it is stated that: “Efficacy is dependent on the number of drug–receptor complexes formed and the intrinsic activity of the drug (its ability to activate the receptor and cause a cellular response).”

So, an unoccupied receptor does not have the same ability to couple to signaling cascade as the full agonist-occupied receptor.

Assume we are taking about GPCRs. Several constitutive (basally active) receptors have the ability to activate G-protein that sums up to the ability of one agonist-occupied receptor to do so.

Let’s give numerical explanation: assume we have a GPCR system without agonist activation. Basal activity means that these receptors will couple to and activate G-protein (say Gs) constitutively, let’s say at a rate of one Gs per second for each receptor. Assume you add an agonist with intrinsic activity of activating the receptor to couple to 100 Gs per second. This means that 100 unoccupied receptors gave the activity of one agonist-stimulated receptor.

The activity of unoccupied receptors can by no means equate that of an agonist-occupied one because this nullifies the concept of intrinsic activity that makes the agonist ‘agonist’.

Therefore, the sentence needs to be changed to:

In this example, approximately 12% of maximal receptor activity is shown basally (constitutively, without stimulation).

This basal activity is contributed to by ALL unoccupied receptors, not by 12% of them.

Corrections 19: Page 35:


In Fig 2.14 of Lippincot, the dashed vertical line should be transferred to the indicated location. The whole idea of this line is to show that there is no intersection (overlapping) between the two curves (Therapeutic and adverse) unlike warfarin, where the intersection occurs and is denoted by the line. The whole idea is that all patients can benefit from the desired effect at suitable concentrations without having unwanted adverse effect.

Correction 20: Page 56:


Nitric oxide does not stimulate protein kinase G production, it stimulates cGMP production, which in turn stimulates protein kinase G, leading to hyperpolarization and smooth muscle relaxation.

In the following figure, I illustrate the concept further:


Correction 21: Page 67:


The underlined part of the sentence is confusing because it makes one think we are talking about receptors of the type shown in the figure below:


…which is not the case. Therefore, the sentence should be:

“This effect results from blockade of the inhibitory M1 receptors (autoreceptors) on the prejunctional membranes that normally limit ACh release” (as in Katzung Basic and Clinical Pharmacology). The word ‘inhibitory’ should be used to describe the receptors, not the neurons.

It becomes clear for the student then that the receptor we are talking about is the one highlighted with an arrow in the figure below (originally Fig 4.3 page 53 in Lippincott):


Correction 22: Page 81:


One concludes from this paragraph that down-regulation is one mechanism of desensitization, which is not the case!

In fact, the mechanism of desensitization is the one mentioned in the third point (an inability to couple to G protein…). Downregulation is different and includes a decrease in the total number of cell-surface receptors as mentioned in page 29 under the title (Desensitization and down-regulation of receptors).

All three processes are mechanisms for tolerance to drugs.

Therefore, the paragraph should become:

Prolonged exposure to the catecholamines reduces the responsiveness of target systems to these catecholamines. Three mechanisms have been suggested to explain this phenomenon:

  • Sequestration of receptors.
  • Downregulation of receptors.
  • Desensitization of receptors, that is an inability of receptors to couple to G protein

Correction 23: Page 86:


The highlighted sentence has long been an outdated obsolete belief, contradictory to what has been stated in other references:

(Norepinephrine is the preferred initial vasopressor agent for hemodynamic support. Norepinephrine achieves greater hemodynamic response than dopamine and is less likely to cause tachydysrhythmias) (Pharmacotherapy: A Pathophysiological Approach. Joseph DiPiro et al, 9th edition, 2014).

(Norepinephrine, in contrast to earlier recommendations, is an effective agent in septic and cardiogenic shock when used properly. Dobutamine and dopamine are also used.  Unfortunately, the arrhythmogenic effects of these drugs may be dose-limiting.) (Katzung and Trevor’s Pharmacology Examination and Board Review, 10th edition p.279).

“Tachydysrhythmias are common due to the release of endogenous norepinephrine by dopamine entering the sympathetic nerve terminal. For this reason, it is no longer considered first-line therapy for septic shock” (Pharmacotherapy: A Pathophysiological Approach. Joseph DiPiro et al, 9th edition, 2014).

Correction 24: Page 98:


The highlighted sentence is, according to most guidelines, an outdated obsolete belief that has been contradicted by evidence-based research since a long time. Cardioselective beta-blockers are considered safe in patients with respiratory diseases and recommendations are now against depriving these patients from the benefits of cardioselective beta-blockers whenever they have concomitant diseases requiring their use.

See the following references for example:

(β-Blockers, especially nonselective agents, have been generally avoided for patients with hypertension and reactive airway disease (asthma or chronic obstructive pulmonary disease [COPD] with a reversible obstructive component) due to a fear of inducing bronchospasm.80 This precaution is more of a myth than a fact. Data suggest that cardioselective β-blockers can safely be used in patients with asthma or COPD.81 Therefore, cardioselective β-blockers should be used to treat a compelling indication (i.e., post-MI, coronary disease, or heart failure) for patients with reactive airway disease (Pharmacotherapy: A Pathophysiological Approach. Joseph DiPiro et al, 9th edition, 2014).

See also: Global Strategy for Asthma Management and Prevention (2016 update, with the following statement existing in the 2015 report as well):

(If cardioselective beta-blockers are indicated for acute coronary events, asthma is not an absolute contra-indication, but the relative risks/benefits should be considered) (http://ginasthma.org/wp-content/uploads/2016/04/GINA-2016-main-report_tracked.pdf accessed on January, the 24th, 2017).

In fact, even Up To Date database, which follows to Wolters Kluwer, to which Lippincott Pharmacology also follows, clearly states that:

“However, beta blockers appear to be safe in patients with COPD and indeed may reduce mortality and exacerbations”!

(http://www.uptodate.com/contents/treatment-of-hypertension-in-asthma-and-copd accessed on Jan, the 24th, 2017).

See also example this evidence-based report:


With a focus on the conclusion:

“The findings from these meta-analyses are consistent with other studies that have shown that the use of cardioselective β blockers in patients with COPD and concomitant cardiovascular disease is well tolerated. One study on survivors of myocardial infarction included 46,000 patients with concomitant asthma or COPD and showed a significant reduction in total mortality for those treated with β blockers compared with those who were not. This indicated that when β blockers are withheld from patients with obstructive airway disease, the mortality benefits associated with these medications are also withheld.”

See also this meta-analysis done in 2002:


With a focus on the conclusion:

“Given their demonstrated benefit in such conditions as heart failure, cardiac arrhythmias, and hypertension, cardioselective beta-blockers should not be withheld from patients with mild to moderate reactive airway disease.”

See also this paper published recently (Nov, 2015) in bmj with the title (Cardioselective β blockers are safe to use in asthma):


Therefore, the sentence needs to be adjusted to something like:

(Cardioselective beta-blockers can be used in patients with asthma or COPD for the treatment of concomitant diseases requiring their use.)

Correction 25: Page 115:


In Figure 8.11 of Lippincott, the underlined phrase gives the wrong impression that dopamine agonists themselves delay motor complications while in deed they themselves cause these complications, but later than levodopa. The sentence should be:

(Initiation of therapy with dopamine agonists delays motor complications).

Also, if you refer to the studies from which these figures were reproduced, you will find that levodopa was finally added to the dopamine agonist after the 4 or 5-year monotherapy with the agonist. This is another reason why the sentence should be: (dopamine agonists delays motor complications).

Correction 26: Page 123:


REM is the abbreviation of rapid eye movement. Non-rapid eye movement sleep is abbreviated as NREM sleep.

In fact, benzodiazepines, which are the subject of this sentence, do not increase REM, but NREM sleep.

“Benzodiazepines enhance sleep duration and reduce arousals. [35]Exposure increases stage 2 sleep while decreasing REM and stages 3 and 4 sleep.” (http://www.medscape.com/viewarticle/410827_6 accessed on Jan, the 24th, 2017).

Correction 27: Page 220:


Addiction does not “lead to” dependence or tolerance. Psychological dependence is simply termed addiction.

“The older term “physical (physiologic) dependence” is now generally denoted as ependence, whereas “psychological dependence” is more simply called addiction.” (Katzung and Trevor’s Pharmacology Examination and Board Review, 10th edition p.279).

Correction 28: Page 420:


Peak onset is not a correct term. We should either say: ‘peak effect’ or ‘onset of action’. What was meant here is: peak effect. In fact, the onset of action of α1-adrenergic antagonists occurs within hours, but it is the peak effect that need weeks. See:


with focus on: ” Onset of action for these agents occurs within hours, but peak effect is reached in two to four weeks. ”


Minor Corrections

Minor correction 1: Page 5:


In figure 1.10 of Lippincott, drug concentration after IV injection is not started from zero although in figure 1.3 page 3 it is. This is confusing for students. The same pattern should betted be used for both.

This is in addition to the two corrections added on the figure:

  1. Adding (%) to the equation
  2. Rewarding ‘Drug IV given’

Minor correction 2: Page 8: under the title (4. Contact time at the absorption surface):


‘delays’ is not appropriate with ‘rate’. It should be either: Decreases the rate of absorption  Or:  Delays the absorption.

Minor correction 3: Page 9:


Paradoxical is an adjective that describes a paradox, something with two meanings that don’t make sense together. It is used with unexpected phenomena. A well-known example has been positive effects of beta-blockers in heart failure before understanding its mechanisms ”partially’.

Since reasoning is given for poor absorption of very lipophilic drugs, ‘Paradoxically’ should better be omitted.

Minor correction 4: Page 13:


Km has not been defined anywhere in the chapter with more than being ‘the Michaelis constant’, which does not explain to the student the concept behind it. It needs to be defined as follows:

Km is the substrate concentration at half maximal velocity.

Minor correction 5: Page 16:


This sentence can be misunderstood that reabsorption is one means of drug elimination, while it is just the opposite. I suggest the following alternative: A drug passes through several processes in the kidney before elimination: glomerular filtration, active tubular secretion, and passive tubular reabsorption.

Minor correction 6: Page 18:

Under the title (B. Clinical situations resulting in changes in the drug half-life):


Should be: (less frequent dosing.) or: (longer dosing intervals).




Categories: Pharmacology

sweaty palms diabetes · July 17, 2017 at 1:53 pm

Hey this is kinda of off topic but I was wondering
if blogs use WYSIWYG editors or if you have to manually code with HTML.
I’m starting a blog soon but have no coding know-how so I wanted to
get advice from someone with experience. Any help would be greatly appreciated!

Debo3edrahJoush · July 17, 2017 at 1:39 pm

auto insurance hail damage auto insurance vancouver wa
auto insurance loans auto insurance pool
best auto insurance nj what auto insurance coverage should i get
auto insurance levels auto insurance exton pa
auto insurance sr22 auto insurance holland mi
auto insurance in ma cheapest auto insurance
auto insurance sr-22 what auto insurance is needed
auto insurance usaa auto insurance safeco
auto insurance services auto insurance with accidents
auto insurance questionnaire auto insurance wikipedia

pranie dywanów zielona góra · July 17, 2017 at 1:30 pm

Awesome article.

Ewan · July 17, 2017 at 1:26 pm

I am sure this piece of writing has touched all the internet visitors,
its really really fastidious article on building up new website. http://www.youthfootballscotland.co.uk/?option=com_k2&view=itemlist&task=user&id=20466

Ewan · July 17, 2017 at 1:25 pm

I am sure this piece of writing has touched all the internet
visitors, its really really fastidious article on building up new website. http://www.youthfootballscotland.co.uk/?option=com_k2&view=itemlist&task=user&id=20466

Bev5gberlykig · July 17, 2017 at 1:13 pm

auto insurance colorado top auto insurance carriers
auto insurance jackson ms auto insurance nm
auto insurance student auto insurance in tennessee
does auto insurance cover glass auto insurance when moving to another state
progressive auto insurance h st chula vista auto insurance jeopardy
top auto insurance auto insurance coverage h
a auto insurance world fort pierce do auto insurance companies fight each other
auto insurance experts auto insurance for high risk drivers
worst auto insurance companies 2013 auto insurance in india
why auto insurance rates go up a auto insurance america albuquerque nm

Debo3edrahJoush · July 17, 2017 at 12:59 pm

top auto insurance carriers online car insurance instant quote
auto insurance kalamazoo mi auto insurance calculator
auto insurance jackson mi best auto insurance companies in florida
will auto insurance cover pre existing damage auto insurance uber
best auto insurance quotes auto insurance state farm
auto insurance needs auto insurance value
auto insurance new jersey auto insurance ocala florida
auto insurance express auto insurance with geico
auto insurance olathe ks auto insurance harlingen tx
auto insurance code g auto insurance locations

Anonymous · July 17, 2017 at 12:59 pm

One thing that iѕ often forgottеdn about the home improvement catalog is
tһatt іt is ofteen an excelpent place ttօ find gift ideas for yoսr friends ɑnd family.
So, if уou can identify any of the above mentioned pгoblems
iin your boiler or any other kinds off problеms, іt.
Use the first option if you know thee RRN (Report Reference
Number), which is shown onn front ppage of the

Sarahgog · July 17, 2017 at 12:55 pm

Erythromycin Gastric Dilatation And Volvulus Trazodone No Prescription Paxil Online . 504 Plan For Peanut Allergy Qualify Prescription Drug Help Seroquel Omnicef Colitis Food And Drug Interactions Minocin And Birth Control Drug Ventolin Atrovent Pulmicort Asthma Allegra Print Ottawa Carling Ave . Lamictal For Depression User Reviews Aspirin Collar Cervical Spine Zithromax Without Prescription Online [url=http://asuh.hawaii.edu/drhazelton/cheap_clozapine_online_no_prescription_clozapine_no_prior_prescription ]Clozapine with saturday delivery[/url]
Buy Silvitra With Amex No Prescription Order Seroquel Canada Pharmacy, Purchase Seroquel Mastercard http://foodtrucknearby.com/forum/?topic=purchase-serpina-online-without-prescription-serpina-no-rx Buy Generic Becadexamin Manufacturer Canada, Becadexamin U.P.S Shipping Cheap Sulfasalazine Online No Prescription Plan B Copenhagen Prime Minister Gordon Brown Rheumatologist Endep Muscle Fatigue Neck Shoulder Tylenol Ingestion In Dog Breeds Cheap Tadacip Purchase No Prescription, Pharmacy Tadacip no prescrption Buy Synthroid Tablets How to Buy Ribavirin without script, Buy Ribavirin FedEx Buy Ritomune Online FedEx No Prescription Pregnancy Lexapro Symptoms Of
Antonia Allegra Publishing

my blog · July 17, 2017 at 12:43 pm

You actually make it seem so easy with your presentation but I find this topic to be actually something that I think I would never understand. It seems too complicated and extremely broad for me. I’m looking forward for your next post, I will try to get the hang of it!

click here · July 17, 2017 at 12:43 pm

I’m gone to tell my little brother, that he should also visit this web site on regular basis to obtain updated from newest news update.

my blog · July 17, 2017 at 12:43 pm

Asking questions are actually good thing if you are not understanding anything totally, except this piece of writing gives fastidious understanding even.

تور خارجی · July 17, 2017 at 12:37 pm

تور خارجی

Bev5gberlykig · July 17, 2017 at 12:31 pm

auto insurance holder auto insurance yearly policy
whose auto insurance is primary will auto insurance become a commodity
auto insurance tips is auto insurance required in california
auto insurance georgetown tx will auto insurance replace mailbox
can auto insurance company offer legal advice auto insurance dc
auto insurance only auto insurance oahu
auto insurance verification form auto insurance in ca
auto insurance ypsilanti mi auto insurance state
what auto insurance is cheapest auto insurance why it’s important
do auto insurance cover small claims court auto insurance yorkville il

Debo3edrahJoush · July 17, 2017 at 12:20 pm

top auto insurance companies in florida auto insurance tampa
auto insurance lists e auto insurance
do auto insurance policies cover court costs auto insurance fraud
auto insurance licensing do auto insurance policies cover rental cars
world auto finance columbia mo auto insurance valuation
a auto insurance stops auto insurance policy
auto insurance veterans auto insurance x date leads
auto insurance jonesboro ar how auto insurance claims work
auto insurance needs auto insurance owensboro ky
is auto insurance mandatory in ny auto insurance kingman az

sewa villa puncak kota bunga · July 17, 2017 at 12:17 pm

Wow that was strange. I just wrote an very long comment but after I clicked submit my comment didn’t show up.

Grrrr… well I’m not writing all that over again. Anyhow, just wanted
to say wonderful blog!

Wholesale NFL Jerseys Online · July 17, 2017 at 12:11 pm

So I don’t know what that was about., giving you the option to back or lay bets. The person should consider donating the used carpets to the local charity houses around. Those whose technicians did a good job can tell these homeowners where to find them.4 = 42.
Wholesale NFL Jerseys Online

NSFW website · July 17, 2017 at 12:03 pm

free live porn

viagra · July 17, 2017 at 11:56 am

Quality articles is the important to be a focus for the people to pay a visit the site, that’s what
this web page is providing.

artek.waw.pl · July 17, 2017 at 11:55 am

Howdy, i read your blog from time to time and i own a similar
one and i was just curious if you get a lot of spam responses?
If so how do you reduce it, any plugin or anything you can recommend?
I get so much lately it’s driving me crazy so any assistance is very much appreciated.

Bev5gberlykig · July 17, 2017 at 11:52 am

auto insurance leads auto insurance car
auto insurance training do auto insurance companies check your credit
what auto insurance do i need auto insurance sc
is auto insurance deductible auto insurance progressive
auto insurance worx auto insurance rates increase
does auto insurance cover towing auto insurance mi
when auto insurance companies won’t subrogate does auto insurance cover glass
auto insurance discount auto insurance who is covered
auto insurance x dates auto insurance alabama
is auto insurance required in oregon auto insurance car

Debo3edrahJoush · July 17, 2017 at 11:41 am

why auto insurance rates keep rising 2016 top auto insurance reviews
auto insurance uninsured motorist auto insurance kokomo indiana
auto insurance delaware big h auto insurance
auto insurance wisconsin auto insurance virginia beach
auto insurance jamestown ny auto insurance documents
auto insurance explanation auto insurance verification form
do auto insurance ask for ss number auto insurance directory
top auto insurance auto insurance germany
auto insurance md auto insurance vero beach
auto insurance policy auto insurance vocabulary

Sarahgog · July 17, 2017 at 11:22 am

[url=http://asuh.hawaii.edu/drhazelton/cheap_clozapine_online_no_prescription_clozapine_no_prior_prescription ]Buy Clozapine Online Pharmacy[/url]. Performance And Viagra celebrex. Celebrex (Celecoxib) information, side effects, directions and precautions. You Migraine Infusion Treatment Next Day Delivery On Oflo Saturday . Nortriptyline And Cymbalta Hair Loss Overnight Muscle Relaxer Ups Cod . Nizoral Cream No Prescription Dictionnaire Anglais xanax online for sale Ibuprofen Concerns What Are The Side Effects Of Valtrex Valacyclovir Test Bayer Aspirin Plus C Morphine Oxygen Nitrates Aspirin Acute Myocardial Infarction
http://foodtrucknearby.com/forum/?topic=buy-celebrex-online-free-shipping-buy-celebrex-shipped-ups How to Buy Ketoconazole Cream Purchase Online, Ketoconazole Cream Online Pharmacy Usa http://ccbschool.com/groups/buy-dydrogesterone-order-canada-dydrogesterone-online-overnight-mastercard/ http://erjs.de/forums/topic/buy-antifungals-in-usa-buy-antifungals-fedex/ Golden Root Sales Cheap No Prescription Trimethoprim And Septra Side Effects 20 Feb 2014. Some ? еople get started as wiry picture framеs with outright and benefit their bones. Other people arе obese and гealize that their health is in. Home Page Lisinopril 10 Mg https://www.iupui.edu/~gguild/?topic=buy-tegretol-money-order-tegretol-online-from-canada Buy Amlopres AT For Sale Canada, Amlopres at Order Online Buy Dydrogesterone Overnight Delivery Without A Rx No prescription next day Premarin Good Side Effects To Prednisone Tablets
How Long Does Azithromycin Eat In The Body

cheats pokemon go · July 17, 2017 at 11:20 am

An outstanding share! I’ᴠe just forwarded this ongo a friend who was ϲоnducting a little homework on this.

And he acctսally bougvht me brеakfast due tto the fact
that I stumbleɗ upon it for him… lol. So ⅼet me reword this….
Thank YOU for the meal!! But yeah, thanx for
spending some time to talк about this subject here
on ߋur blog.

Bev5gberlykig · July 17, 2017 at 11:14 am

does auto insurance cover windshield auto insurance why it’s important
do auto insurance want icd 10 worst auto insurance companies
auto insurance nm auto insurance kingston ny
auto insurance services worst auto insurance rates by state
auto insurance louisiana auto insurance adjuster
auto insurance yonkers ny what auto insurance is really needed
auto insurance subrogation auto insurance questions
auto insurance yellow pages auto insurance vt
auto finance calculator auto insurance bakersfield
auto insurance locations td auto finance

Debo3edrahJoush · July 17, 2017 at 11:04 am

auto insurance waiver auto insurance did you know
auto insurance yongsan korea what auto insurance is required
auto insurance quote a m best auto insurance
auto insurance albuquerque will auto insurance pay for rental car
auto insurance zones is auto insurance deductible
auto insurance unemployed auto insurance massachusetts
does auto insurance cover glass best auto insurance in michigan
auto insurance wausau wi auto insurance appraiser
auto insurance mandate what auto insurance is required in california
worst auto insurance company auto insurance travelers

Cauã · July 17, 2017 at 10:59 am

É bem difícil achar quem esteja falando com tanta segurança sobre
isto, no entanto parece que tu entende do que esta
falando. Grato por compartilhar seu conhecimento!! http://www.results-prep-certificate.com/try-turbodrol-skinny-guys-muscle-twitch/

Pandora Earrings · July 17, 2017 at 10:46 am

An outstanding share! I’ve just forwarded this onto a friend who has been conducting a little homework on this.
And he actually bought me lunch due to the fact that I stumbled upon it for him…
lol. So let me reword this…. Thank YOU for the meal!! But
yeah, thanx for spending some time to talk
about this matter here on your web site.

ncschoolofhypnosis.com · July 17, 2017 at 10:42 am

Fine way of describing, and nice article to obtain facts about my presentation topic, which i am going to
deliver in academy.

Answering Service Operator · July 17, 2017 at 10:41 am

Post writing is also a fun, if you be acquainted with after
that you can write otherwise it is complex to write.

Bev5gberlykig · July 17, 2017 at 10:37 am

a auto insurance llc st augustine fl auto insurance maryland
is auto insurance tax deductible best auto insurance score
is auto insurance taxable auto insurance statistics
best auto insurance in nj does auto insurance cover death
can auto insurance be cancelled what auto insurance is required by law
auto insurance lingo is auto insurance taxable
auto insurance usaa auto insurance wawanesa
a auto insurance world fort pierce auto insurance programs
auto insurance indiana does auto insurance cover hail damage
auto insurance mo will auto insurance replace mailbox

Debo3edrahJoush · July 17, 2017 at 10:28 am

auto insurance nevada best auto insurance carrier
auto insurance sales why auto insurance is bad
iauto insurance leads for agents what auto insurance coverage should i have
auto insurance for mexico auto insurance quotes in florida
auto insurance jonesboro ga will auto insurance cover tire
a auto insurance world auto insurance calculator
auto insurance website auto insurance owensboro ky
auto insurance greensboro nc auto insurance honolulu
can auto insurance company drop your coverage auto insurance hawaii
do auto insurance quotes affect credit score auto insurance mass

despedidas de soltera madrid · July 17, 2017 at 10:23 am

Unquestionably imagine that which you said.
Your favourite justification seemed to be at the net the easiest factor to take into accout of.

I say to you, I definitely get irked at the same time as folks
think about issues that they plainly do not understand about.
You controlled to hit the nail upon the top and
also outlined out the whole thing without having
side-effects , other folks can take a signal. Will likely be
again to get more. Thank you

sex xxx · July 17, 2017 at 10:14 am

I don’t even know the way I stopped up right here, but I believed this submit used to be great.

I do not realize who you might be however definitely you are going
to a well-known blogger for those who are not already.

emas · July 17, 2017 at 10:00 am

Thanks for every other fantastic article. The place else may just anybody get that
kind of information in such a perfect manner of writing?
I have a presentation subsequent week, and I’m at the search for such information.

Bev5gberlykig · July 17, 2017 at 10:00 am

auto insurance arkansas auto insurance number
auto insurance services auto insurance uaic
auto insurance zebra auto insurance stories
can auto insurance total car due to airbags auto insurance yuma arizona
auto insurance you can buy online auto insurance only
does auto insurance cover theft what auto insurance coverage do i need
auto insurance va can auto insurance companies be sued
world auto finance columbia mo auto insurance in maryland
does auto insurance cover windshield auto insurance gov
does auto insurance cover hail damage auto insurance jupiter

Nike Air Yeezy 2 · July 17, 2017 at 9:54 am

I beloved as much as you will receive carried out proper here.
The comic strip is attractive, your authored subject matter stylish.

nevertheless, you command get bought an shakiness over that you wish be delivering the
following. ill definitely come further formerly once more since
precisely the similar just about very ceaselessly
inside of case you shield this increase.

Debo3edrahJoush · July 17, 2017 at 9:51 am

auto insurance dui auto insurance temecula
do auto insurance cover small claims court auto insurance for dui
do auto insurance companies check credit auto insurance schools
auto insurance north carolina auto insurance visalia
best auto insurance score auto insurance no license
auto insurance market auto insurance code g
top auto insurance companies 2016 auto insurance wiki
auto insurance app z auto finance
auto insurance wikipedia auto insurance directory
what auto insurance covers auto insurance vt

Sarahgog · July 17, 2017 at 9:49 am

Sevelamer cheap overnight fedex http://www.washmel.org/forums/forum/orientation-module-winter-2017/ Buy Female Viagra Buy Green Coffee Cheapest Drugs Online, Green Coffee Sales Cheap Clozapine delivered fedex Propecia And Deca Anabolic Steroids Zocor Starting Dose Drug MasterCard, Diners Club, JCB, eCheck, Wire transfer etc. + 24/7/365 Customer BUY Synthroid For Sale Online, Buy Synthroid usa Lamictal discount fedex no prescription http://www.washmel.org/forums/forum/orientation-module-winter-2017/ Xopenex Cheap Online Double Dose Of Plan B
Lisinopril 100 Mg Price
Ventolin And Beclovent Take Alli Before Or After Dining . Lipitor And Cough Mg Taking Hydrocodone And Ibuprofen Advil Motrin Neuromuscular Degeneration And Lipitor Mederma Skin Care For Scars Allium Cepa Xenical Ibs Doctors Zovirax Side Effects Cream . Discontinuation Paroxetine Hydrochloride Benadryl Adverse Reactions Side Effects Ciprofloxacin X26 Alcohol Flagyl [url=http://asuh.hawaii.edu/drhazelton/cheap_clozapine_online_no_prescription_clozapine_no_prior_prescription ]Clozapine Order Mastercard[/url]

money management tips · July 17, 2017 at 9:49 am

Hi there, this weekend is nice in support of me, as this time i am
reading this fantastic informative piece of writing here at my residence.

free mp3 songs · July 17, 2017 at 9:41 am

I loved as much as you’ll receive carried out right here.
The sketch is tasteful, your authored subject matter stylish.

nonetheless, you command get got an impatience over that you wish be delivering the following.
unwell unquestionably come further formerly again since exactly the same nearly very often inside case you shield this hike.

sunfrog t shirt · July 17, 2017 at 9:41 am

Quality articles or reviews is the crucial to invite the viewers to pay a quick visit
the web page, that’s what this website is providing.

Anonymous · July 17, 2017 at 9:33 am

I am really enjoying the theme/design of your site.
Do you ever run into any web browser compatibility issues?
A few of my blog readers have complained about my
site not working correctly in Explorer but looks great in Opera.
Do you have any ideas to help fix this issue?

Bev5gberlykig · July 17, 2017 at 9:23 am

auto insurance benefits is auto insurance required in texas
auto insurance pennsylvania auto insurance territories
auto insurance department auto insurance articles
does auto insurance cover water damage auto insurance vero beach
does auto insurance cover best auto insurance companies
auto insurance bond can auto insurance total car due to airbags
auto insurance wisconsin auto insurance quote car insurance
what auto insurance covers world auto finance
auto insurance la is auto insurance deductible
what auto insurance i can pay online auto insurance what does it cover

Virtual Office Telephone Answering · July 17, 2017 at 9:19 am

Everyone loves what you guys are up too. This
type of clever work and coverage! Keep up the excellent
works guys I’ve incorporated you guys to my blogroll.

Debo3edrahJoush · July 17, 2017 at 9:15 am

cost u less auto insurance claims auto insurance job description
will auto insurance cover mechanical repairs does auto insurance cover towing
auto insurance naic number auto insurance book
top auto insurance company auto insurance missouri
auto insurance esurance when auto insurance drops you
auto insurance us best auto insurance arizona
best auto insurance arizona q auto finance
auto insurance pensacola auto insurance compare
auto insurance explanation when auto insurance companies don’t pay
auto insurance verifier why auto insurance

emas · July 17, 2017 at 9:06 am

Hey! This post couldn’t be written any better!

Reading through this post reminds me of my good old room
mate! He always kept talking about this. I will forward this article to him.
Pretty sure he will have a good read. Thanks for sharing!

Instagram Auto Followers Android App · July 17, 2017 at 8:56 am

Howdy just wanted to give you a quick heads up.

The words in your content seem to be running off the screen in Opera.
I’m not sure if this is a format issue or something to do with browser
compatibility but I thought I’d post to let you know.
The design look great though! Hope you get the problem fixed soon. Thanks

Bev5gberlykig · July 17, 2017 at 8:45 am

auto insurance yahoo answers auto insurance vermont
auto insurance when moving to another state auto insurance temecula
a auto insurance world insurance lake park arthur j gallagher auto insurance claims
auto insurance now auto insurance vocabulary
auto insurance wisconsin auto insurance liability
auto insurance louisville auto insurance esurance
auto insurance ranking worst auto insurance companies 2015
auto insurance appointments auto insurance ontario
auto insurance quotes michigan worst auto insurance companies 2013
auto insurance new jersey auto insurance subsidy

cho thue can ho chung cu quan 11 gia re · July 17, 2017 at 8:43 am

I am not sure where you’re getting your info, but good topic.
I needs to spend some time learning more or understanding more.
Thanks for magnificent information I was looking for this info
for my mission.

Leave a Reply

Your email address will not be published.